Ya jugados todos los partidos correspondientes a la cuarta fecha del certamen, así quedó la tabla de posiciones del Clausura 2021 de Primera A masculina, organizado por la Liga Regional de Fútbol de Río Cuarto.
| Pos | Equipo | PTS | PJ | PG | PE | PP | GF | GC | DIF |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Municipal Adelia María | 12 | 4 | 4 | 0 | 0 | 9 | 1 | 8 |
| 2 | Ateneo Vecinos | 10 | 4 | 3 | 1 | 0 | 9 | 3 | 6 |
| 3 | Lutgardis Riveros | 8 | 4 | 2 | 2 | 0 | 12 | 7 | 5 |
| 4 | Belgrano de Mackenna | 8 | 4 | 2 | 2 | 0 | 10 | 7 | 3 |
| 5 | Atlético San Basilio | 8 | 4 | 2 | 2 | 0 | 5 | 2 | 3 |
| 6 | Atlético Adelia María | 6 | 4 | 2 | 0 | 2 | 9 | 8 | 1 |
| 7 | Atenas | 5 | 4 | 1 | 2 | 1 | 7 | 6 | 1 |
| 8 | Lautaro Roncedo | 4 | 3 | 1 | 1 | 1 | 8 | 7 | 1 |
| 9 | Atlético Sampacho | 4 | 4 | 1 | 1 | 2 | 6 | 5 | 1 |
| 10 | Juventud Unida Río Cuarto | 4 | 3 | 1 | 1 | 1 | 4 | 4 | 0 |
| 11 | Acción Juvenil | 4 | 4 | 1 | 1 | 2 | 5 | 6 | -1 |
| 12 | Herlitzka | 4 | 4 | 1 | 1 | 2 | 2 | 4 | -2 |
| 13 | Municipal | 4 | 4 | 1 | 1 | 2 | 2 | 6 | -4 |
| 14 | San Martín de Mackenna | 3 | 4 | 0 | 3 | 1 | 2 | 5 | -3 |
| 15 | Toro Club | 3 | 4 | 0 | 3 | 1 | 4 | 8 | -4 |
| 16 | Estudiantes | 2 | 4 | 0 | 2 | 2 | 1 | 6 | -5 |
| 17 | Everton Club | 2 | 4 | 0 | 2 | 2 | 0 | 5 | -5 |
| 18 | Alberdi | 1 | 4 | 0 | 1 | 3 | 4 | 9 | -5 |